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Wednesday, September 1, 2010

The Teutoburg Forest & The Mind

In September one year more than two millennia ago, the Battle of Teutoburg Forest unfolded. I found great sources of information on the incident in Jona Lendering's account posted on livius.org and in this wikipedia entry with the title "Clades Variana". The legend of this confrontation between occupying Romans and occupied Germans gained great notoriety in 19th- and early 20th-century Germany, where it was used as rallying point for the rise of fervent nationalism.

At the time of the battle, in Emperor Augustus' reign, the Romans had been present on the Rhine for two centuries, had founded prosperous cities and towns along the river and had pushed their zone of influence into regions North and East. However, governance was not stable and needed consolidation in order to establish an actual province. In 55 year-old Publius Quinctilius Varus, Rome sent an ambitious governor of first-rate pedigree to the region with the task to achieve this aim. Varus was a seasoned administrator, but had little insight into local politics and was inexperienced as a military leader. His first act of governance was to implement a rigorous tax system according to Roman law, without consulting and seeking a consensus with the local warlords. Some apparently had a lot to lose under the new system.  In addition, the consolidation of Roman power East of the Rhine would bring settlement of retired Roman military personnel to the region, limiting the free reign of the local tribes. Under the pretense of fighting for independence from the Romans and of liberating the tribes from the Roman tax yoke, these warlords sought alliances among the German tribes to conspire against Varus. One tribal chieftain formally allied with the Romans became a major clandestine leader of the insurgency. His name was Arminius, chief of the Cheruscans.

Over the centuries of building their empire, the Romans had developed an intriguing policy of binding subdued ethnic tribes to their culture, which proved profoundly successful in solidifying their hold over conquered lands. In an expansionary military campaign, the leading general of the invading force would commonly ask for young children as hostages from the noble families of the subdued tribes. They were routinely sent to Rome where they were hosted by affluent families, providing them with a good education. They spent several years there, before they were allowed to return home, learning to appreciate the ways of the Romans. They would learn to speak, read and write the language. They would assimilate the ways the Romans thought and, certainly, learned to love Roman amenities like the free public baths and swimming pools with their impressive architecture and beautiful mosaics, the seemingly never ending supply of cool clean drinking water dispensed from magnificent fountains in every neighborhood, as well as the in-house toilets and the sewage system. Not to mention the culinary adventures, Roman cuisine offered. Imagine chilled fruits in the summer! People stored ice from Alpine glaciers underground. Moreover, the city offered unlimited entertainment in parades, festivals, sports events, theater and games. Life in Rome must have seemed on a different planet compared with life back home. Rome delivered memories these 'guests' would not forget.

Arminius, courtesy P. Heather
Arminius had spent his youth growing up as a hostage in Rome. He was trained in horsemanship and received the title of equestrian. He knew the Romans well and had collaborated closely with them after his ascend to power at home. The Romans considered him a trusted ally. We do not precisely know what turned this seemingly loyal ally against Varus. But it is likely that Varus with his brash reforms rankled him enormously, because they cut into his income stream. While continuing to profess friendly relations, he and others decided to set a trap for Varus. They staged an uprising against Roman rule on the low-lying Northern planes of Germany. To quell the rebellion, Varus mobilized three legions, approximately 25,000 soldiers, to march under his command North from their quarters on the lower Rhine. Arminius and a small retinue of his warriors accompanied the army. What happened next has remained much speculation. We do not even know for sure, where the ensuing confrontation precisely took place. The most likely location is a small valley known as Kalkrise near the modern city of Osnabrück.

By the time the Roman legions reached this location, the column of the slowly advancing force had stretched out many miles. The advance guard, main body, and rear guard had become disjointed. The troops filed through a corridor flanked by low forested hills. The weather was bad. Rainfall had softened the ground. Progress slowed even further. Arminius and his men disappeared. The insurgents had laid an ambush, and the trap snapped close. Without prior warning, javelins and spears poured from the forest onto the unprotected flanks of the troops drudging along in the morass on the open ground. The awkwardly moving mass of men and materiel mustered little defense. Encouraged, the enemy closed in and wreaked havoc in the midsection of the column. The advance guard met a camouflaged wall of palisades that the insurgents had erected in the weeks before and from which they savagely attacked the arriving legionaries. The soldiers accomplished to re-group, undertook counter-attacks, waged break-outs and put up valiant resistance for four days. But the enemy forces grew continuously. Their onslaught remained unrelenting. The Roman resistance eventually succombed, and the troops were obliterated. Some, among them the cavalry, fled the battlefield. Others reached a fortified forward base. Most fell in battle. Some committed suicide. The Germans customarily tortured and killed captured enemy. Faced with such destiny, Varus and his officers ended their lives.

As a result of the debacle, subsequent Roman administrations rescinded the ambition to extend permanent rule further East and focused on consolidating their power West of the Rhine. It would be false to interpret this policy change as weakness. The Romans were not afraid of another confrontation with the Germanic tribes. Rather, Varus' successors saw no significant gain in such enterprise. Certainly, Arminius was not allowed to enjoy his victory for long. Eight legions defeated his insurgency seven years later. The Romans kept relentlessly on his heels. His pregnant wife was taken as hostage to Rome, and Arminius met a violent end before he reached the age of 40. The rebels began to quarrel amongst themselves, and he was assassinated on the behest of another warlord.

Hermann's Monument
German romanticism inflated the historical significance of Arminius' military success out of proportion, basking in imagined superiority of Germanic culture. After the Napoleonic wars, a colossal statue of Hermann, as he is known in German, was erected in Teutoburg Forest to celebrate German unity. Though Hermann's feat looms as large in German lore as his statue is tall, in fact, Roman influence left far deeper, indelible marks on German history. Under Roman rule, the region would enjoy 200 years of stability and peace, known as Pax Romana or Pax Augusta, a length of time unrivaled to the day. Latin was used as the official language of public administration and spiritual life for more than 1,000 years. Still today, Roman laws regulate landownership in Germany; properties are marked by cornerstones.

The Romans possessed an extraordinary gift for effective public administration and superb civil engineering. Within three days, Augustus in Rome knew of the demise of his legions in Germany. When he was informed of the disaster, the emperor reportedly was so shocked that he choked on his dinner and exclaimed in exasperation, "Varus, bring back my legions!" The sudden loss of three entire legions was no small incident. The Roman Empire maintained 28 at the time. The distance between the battlefield and Rome covers roughly 700 miles. We have to cross the Alps. How could the Emperor be informed so quickly?

The Romans had built a network of highways and a messenger service, not unlike the Pony Express, that afforded them such rapid communication across their sphere of influence. Being informed in timely fashion has been a recipe for success then and now. Alas, intelligence needs to be adequately assessed. Varus had been warned by an informant in advance of Arminius' betrayal, but chose to ignore the warning. Perhaps, the most relevant lesson we can learn from the Battle of Teutoburg Forest today is that in an insurgency partners by necessity possess limited value.

Addendum
  • Even powerful emperors depended on the support of Rome's eminent families represented in the Senate. The size of the home of this senate may illustrate the efficiency of Roman government in Augustus' reign. The building is located on a small elevation at the edge of the Forum.


    Curia Julia
    Outside was the fabled navel of the Earth. The Romans made the decisions that determined the fate of their empire in a building the size of a barn (09/22/10).

Thursday, July 22, 2010

Science, Art & Deception of the Mind

In his investigative report with the title "The mark of a masterpiece" published July 12, 2010, in The New Yorker, David Grann informs us about the novel use of methods adopted from forensic science to authenticate works of art. Deception seems intricately interwoven with art. Grann's fascinating story informs us about the scientific method and the power of deceit. It tells us about people who become vulnerable to deception and exploitation on their quest for affirmation of their believe because of pride, ego and money. Establishing the provenance of a masterpiece mainly relies on the subjective expertise to date. However, the desire to discover a new masterpiece by a fabled artist may obfuscate judgment and reason. Definitive objective prove is, therefore, highly sought after.

David Grann portrays the art expert Peter Paul Biro. Biro gained distinction in the world of art for using cutting-edge scientific methods to successfully identify fingerprints of famed masters like Turner, Pollock and Leonardo on hitherto-unknown paintings and drawings. He employs spectral microscopy and computer-supported image analysis to derive his conclusions.

We tend to believe that we are able to establish veracity beyond any doubt with hard data produced by objective machines that do not posses vested interests in the outcome of the examination. However, as David Grann's investigation elegantly reveals, the interpretation of the data may entirely lie in the hands of the investigator. He takes sole responsibility of deciding whether the evidence is sufficient to prove the identity of the fingerprint in question.

Because of our fallibility, more than one expert commonly shoulder such decisions. Peter Paul Biro states that he developed his own imaging equipment, which is one of a kind. No other expert could be asked to verify his findings because they lack the experience with the revolutionary methods he devised. The burden of prove rests with him alone.

This situation puts Biro in a unique position of extraordinary responsibility. The scientific method insists on the reproducibility of findings, preferably by independent examination. Additional verification with different methods may be necessary. Peter Paul Biro is intending to use DNA profiles from hair samples for this purpose. As the only expert in his method, he must know that his career and future depend on his truthfulness. Any scientist's credibility is intimately linked to her/his integrity. Deliberate misrepresentation of evidence is a serious offense, destroying the most highly-respected reputation.


Addenda
  • Anyone versed in fluorescence or confocal microscopy could quickly learn how to image fingerprints. You may not even need a microscope. The detective in the video uses a magnifying glass to examine them. A CCD camera with a macrolense on a solid stand will suffice. A a high-quality light source and fiber optics are needed to produce sufficient illumination of the specimen as well as light filters for the wavelengths at which the images need to be captured. For storage and processing we need a computer with frame grabber and software.  In total, the equipment may not cost more than $100,000.-. The software for the described image treatment, that is background correction and subtraction, contrast enhancement and erosion to lay bare patterns, alignment and overlay of images as well as subsequent differentiation can be achieved with Wayne Rasband's ImageJ. The application is java-based freeware and can be downloaded from Wayne's National Institutes of Health site. The site also provides helpful information on equipment. For statistical analysis, we could quantify the number of picture elements, also known as pixels, in which the compared fingerprints overlap and use pixel-by-pixel paired t-tests to assess statistical significance as measures of identity. According to Grann, Biro charges $1,000.- per day for his qualitative analyses of fingerprints. His judgment must account for most of the cost (07/22/10).
  • Bryony Jones reports in her post with the title "Museum discovers 'new' painting" published online by CNN on Mar. 23, 2012, on an excellent example demonstrating how improved X-ray spectrography helped authenticate a Van Gogh painting previously attributed to an imitator. The painting depicts a still-life of summer flowers exhibited in the Kröller-Müller Museum in Otterlo, the Netherlands. It had been examined with less powerful X-ray methods before, and it was known that there was another composition underneath. Using the new imaging method, experts unambiguously uncovered under the still-life two wrestlers entangled in a match known to have been painted by the famous painter. In addition, the method confirmed that the pigments in the paints were consistent with those used by Van Gogh at the time. Modern technology correctly applied helps (03/24/2012).
  • On rare occasions, identification seems straight-forward. The proud new owner of this Renoir rediscovered comments: “One man's trash is another (wo)man's treasure!” (09/12/2012):
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Tuesday, July 6, 2010

The Human Genome: A False Promise?

Genomic medicine, also known as personalized medicine, has become a universal buzz word, perhaps to attract more dollars to biomedical research. Only two months ago the new Director of the National Institutes of Health and former Director of the National Human Genome Research Institute Francis Collins announced the age of personalized medicine in the national media. In short, the sequencing of a person's genome will become less costly and available to everyone in the near future. Based on our genetic makeup, doctors will be able to treat prospective illnesses before they have a chance to afflict us. This country's biomedical research establishment invested billions of dollars in this idea.

Then, three weeks ago the new Director of the National Cancer Institute, scientific adviser to the president, and former Director of the National Institutes of Health Harold Varmus stated in the news that human genomic research is only useful to science at present. Nicholas Wade's article entitled "A Decade Later, Genetic Map Yields Few New Cures" and Andrew Pollack's article entitled "Awaiting the Genome Payoff" were published in The New York Times on Jun. 12 and 14, 2010, respectively, in the wake of what must seem like an about-face at the highest level of leadership in U.S. biomedical research. In both articles, the short-term prospects of personalized medicine seemed less certain.

Alas, understanding the human genome in health and disease is doubtlessly spawning important progress on numerous fronts in medicine. The discovery of modified genes in cancer cells and the proteins they encode is being used to develop novel chemotherapies. In particular, drugs for targeted therapies are currently being tested that may counteract the averse effects of modifications in genes KRAS and BRAF in a variety of cancers. In yet another advance, we may be able to adapt our diet to our personal genetic makeup with a better promise of controlling our weight, diminishing our risk for cardiovascular disease.

By contrast, uncovering the genetic bases of mental disorders like autism and schizophrenia has proved difficult. The findings to date suggest that such disorders are the result of highly complex interactions of a multitude of molecular signaling pathways involving many genes. Whether genomic research can benefit therapies to treat such mental disorders remains to be seen.

Addenda

  • Recent studies uncovered a mutation of the gene ALK in tumor tissue of people with non-small cell lung cancer. ALK encodes the enzyme anaplastic lymphoma receptor tyrosine kinase. The fusion of this gene with the gene EML4 renders a tyrosine kinase persistently active that prevents programmed cell death from curtailing neoplastic growth.  Aaron Saenz describes a potential drug treatment using this important finding in his post entitled "Crizotinib Targets Gene To Stop Lung Cancer Tumors in 90% of Treated Patients" on Singularity Hub dated Jun. 9, 2010. No doubt, the development of drugs specifically targeting such cellular malfunction is highly desirable. However, less than four percent of lung cancer patients carry the EML4-ALK fusion, and the drugs tested to date only slow the progress of the disease. Personalized medicine definitely needs more research, time and money to come to fruition (08/05/10).
  • Peter J. Boyer wrote an informative essay with the title "The Covenant" about Francis Collins and his goals as the new Director of the National Institutes of Health. The essay was published online Sep. 6, 2010, in The New Yorker (09/10/10).
  • Because targeted therapies are expensive and may produce varying results, we may be confronted with difficult choices. This conversation between Paul Raeburn and Leonard Fleck entitled "Looking at the Ethics of Personalized Medicine" broadcast yesterday on NPR's Science Friday informs us about the dilemma inherent in this issue (09/25/10).
  • Julie Steenhuysen's report with the title "Gene tests inadvertently exposing cases of incest" posted yesterday on Reuters provides a striking example for personalized medicine's potential of uncovering information that raises ethical questions (02/11/11).
  • According to Sharon Begley's article on Reuters with the title "DNA pioneer James Watson takes aim at 'cancer establishments'" published online today, the co-discoverer of the molecular structure of DNA, Nobel-laureate, and eminent proponent for the human genome project J.D. Watson now believes that our greatest hope for fighting cancer is the use of antioxidants. That is, boosting antioxidants may help prevent cancer and blocking their actions in tumor cells may help with a cure. His voice lends credence to those who cautioned against excessive expectations in the promise of personalized genomic cancer medicine (01/09/2013).
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