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Showing posts with label Switzerland. Show all posts
Showing posts with label Switzerland. Show all posts

Sunday, October 3, 2010

Morat-Fribourg, 2010

Today, the historic run from Morat to Fribourg in Switzerland was held for the 77th time (erratum: My count was one off, when I posted first). The run over a distance of slightly more than 16 miles (17.170 km) commemorates a decisive battle the Suisse Confederation won against the Burgundians in 1476. The Suisse retained their independence.

Today's race winners are:

Jane Muia (1:03:33.0), Kenya,

and Fredrick Musyo (52:53.4), Kenya,

closely pursued by Daniel Kiptum, Switzerland (52:53.7).

Congratulations! Free will exists!

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Friday, October 23, 2009

Free Will Exists: Morat Fribourg, 2009

This year's race from Morat to Fribourg, held Oct. 3 in its 76th edition (erratum: My count was one off, when I posted first), was won again by Helen Musyoka (1:01:29 h) and John Mwangangi (0:52:37 h), both from Kenya. Congratulations!

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Thursday, October 30, 2008

The Departure of the Cranes

“Today, the solitary inventor, tinkering in his shop, has been overshadowed by task forces of scientists in laboratories and testing fields. In the same fashion, the free university, historically the fountainhead of free ideas and scientific discovery, has experienced a revolution in the conduct of research. Partly because of the huge costs involved, a government contract becomes virtually a substitute for intellectual curiosity. For every old blackboard there are now hundreds of new electronic computers. The prospect of domination of the nation’s scholars by Federal employment, project allocations, and the power of money is ever present — and is gravely to be regarded.” President Dwight D. Eisenhower in his 1961 farewell address (added 01/17/2011).
Grus grus.
I used to live near a region that was once known for its cranes (Grus grus). They were so abundant that the region took its name from them, and the lords who ruled this land adopted them as central theme in their coat of arms which today adorns the local pottery. The landscape is bucolic. Small villages and towns dot green rolling foothills rising toward distant altitude above the timberline. Modernity and history are interwoven here in natural growth. Below the picturesque castle of the ancient lords and attached medival town, the visitor may be surprised to find the facilities of a contemporary college with American accreditation.

The cranes have become a rare sight today and the region is better known for its cheese. Only the patient may notice a lonesome bird early in the morning standing tall and motionless in the shallow water near the reedy banks of a quiet pond. Over time, the observant develops a keen eye for these graceful creatures and may be able to spot them on occasion in passing from the window of a commuter train carrying people off to work. I have not been on that train in two decades. But according to the most recent check list, the cranes are still about.

The pottery.
Ever since I left that land, I have become familiar with a different kind of crane on my visits to academic institutions in this country. You can spot them easily from afar. These cranes are usually clustered around tall stately buildings under construction. In the past eight years, endowment portfolios at private research universities and medical schools accrued with solid gains. Intense fund raising swelled donations. Credit for new construction was cheap. The institutions embarked on a building spree.

A number of these edifices with facades of blue glass, white columns and brown stone tile are going to house academic medical centers. With the aging of the baby boomers, the demand on health care will amplify profoundly. According to the Health Work Force Institute, 2.5 million registered nurses will be needed in 2020. At present, new degree programs in affiliated health sciences are being created in great numbers across the U.S. In my area, nursing schools have doubled in two years. Local universities as Belmont University are expanding their health science programs. Doubtlessly, new health care facilities are necessary.

On the other end of the spectrum, I saw many construction projects that were slated for biomedical research laboratories. Despite the current funding crunch that I discussed in my post dated Oct. 1, universities and medical schools look fondly upon biomedical research because of its prestige and the money that it attracts. Research grants from federal agencies do not only cover laboratory supplies and equipment, but also a significant portion of faculty and staff salaries. That is why, medical schools can afford to maintain large faculties in excess of the demand of clinical service. For example, I counted 81 faculty members in Neurology at the University of Pennsylvania.

In addition to the direct cost for research, the federal agencies provide host institutions with a percentage of direct cost to help defray overhead expenses for infrastructure, administration and basic services like utilities and plant operations. The indirect cost recovery rate is negotiated with each institution. For example, the rate of the University of Pennsylvania was 59.5 percent in 1999, but could be 100 percent and more in other cases. Some institutions charged overhead excessively, were audited, and eventually fined (Federation of American Scientists Report #91095). The system was revised. Administrative cost was capped at 11 percent.

Overhead recovery rates that are representative for the country at present are hard to find. The University of Michigan currently recovers 54.5 percent. At a presumed rate of 60 percent, a medical school that attracts about 200 million dollars in direct cost for specific research from federal agencies annually (not an unheard-of amount), will receive another 120 million unspecified dollars for indirect cost recovery. This sum would approximately cover the investment for a new five-story research building. The more square feet of laboratory space a university adds, the more investigators can pursue federally funded research, the greater the returns for the institution, inviting yet another clone of a research building. I believe that this chain reaction fueled the current construction boom, boding ill for the future. The cranes may disappear soon.

First, federal funding for biomedical research has been eroding over the past 10 years in the face of a steadily rising number of applications. According to the National Institutes of Health Office of Extramural Research, the grand total average success rate of grant applications fell from 34.2 percent in 1997 to 24.4 percent in 2007 (see success rate table at NIH funding).

In addition, the investment portfolios of endowed research institutions shrank catastrophically in recent weeks and credit has all but dried up. American private universities are commercial enterprises. In his congressional hearing, the former CEO of Lehman Brothers, Richard Fuld, named the exposure to commercial mortgages as the prime cause of his bank's downfall. National Public Radio's All Things Considered broadcast this snippet of his testimony entitled "Lehman CEO Testies On Capitol Hill" on Oct. 6.

On top, private universities are linked into astronomical increases in college tuition and fees. According to Tamar Lewin's in The New York Times on Oct. 29 with the title "Downturn Expected to Drive Tuition up", tuition and fees are about to exceed $50,000.- per academic year for some institutions, forcing them to offer substantial financial aid to attract academically qualified students. If the portfolios of these universities do not recover soon, some may find themselves unable to service their debt.

When you are looking for a college these days, you may wish to read my post dated Jan. 24, 2008, and re-assure yourself that there are not too many cranes on campus.

Addenda
  • Tamar Lewin filed a second report report on this issue with the title "Tough Times Strain Colleges Rich and Poor" in The New York Times today. It is quite consistent with the observations above (11/08/08).
  • Charles Bagli aptly describes in his report with the title " As Vacant Office Space Grows, So Does Lenders' Crisis" in The New York Times today, the problems afflicting commercial mortgages that Mr. Fuld regretfully recognized in retrospect as lethal to his bank (01/04/09).
  • Reuters Health and Science Editor Maggie Fox reported in her post with the title "U.S. hospital profits fall to zero: Thompson Reuters" today that, according to a recent Thomson Reuters Healthcare survey of more than 400 profit and non-profit U.S. hospitals, the examined institutions were not able to generate surplus revenue for new infrastructure expenditures already in the third quarter of 2008. Because of losses in investment portfolio and slowed medical insurance reimbursements, half of the hospitals were operating at loss. The study was discussed in Janet Babin's segment on National Public Radio's Marketplace with the title "Hospitals ailing with financial stress" on the same day (03/02/09).
  • I just finished my walk around the campus of Vanderbilt University and counted among the university-owned real estate projects completed since my arrival in 1994: four complexes housing offices, hotels and/or retail, four apartment complexes, eight large multi-storied parking garages,  four large dormitories on a commons, three student centers, a baseball stadium, a totally refurbished football stadium, six large and three small research buildings, a new wing for the School of Engineering, a new School of Music, a new School of Law, a new School of Business, a new School of Nursing, two large and one small hospital buildings, plus one large outpatient clinic just completed. I neither counted major renovation projects, nor may my list be complete. The total of the investment may roughly amount to as much as 2.4 billion dollars. That is, the university spent the equivalent of its entire current endowment on the expansion of infrastructure (03/29/2009).
  • National Public Radio's Market Place broadcast an interview of Kai Ryssdal with Chronicle of Higher Education reporter Paul Basken entitled "Stimulus creates application avalanche" today on the implications of this year's 10.4 billion dollar stimulus for the National Institutes of Health (NIH) to fund scientific research at academic institutions. About 115,000 grant applications were filed with the NIH so far this year, constituting a 1.5-fold increase over last year's 77,000. About 21,000 grant applications directly targeted the stimulus funds (06/09/09).
  • Today Gina Kolata reports in her article for The New York Times entitled "Playing it Safe in Cancer Research" that the NIH may be able to fund roughly one percent of the applications for economic stimulus-financed grants known as challenge grants (06/27/09).
  • As an example in support of my own impressions, Richmond Times Dispatch writer Karin Kapsidelis reports in her article with the title "Rising cost at Virginia’s universities mostly unrelated to instruction, study says" published online Jun 10, 2013, by the Daily Progress that Virginia public research universities have increased infrastructure spending over the past two decade, while investment in instruction declined (06/15/2013).
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Thursday, October 9, 2008

Free Will Exists

Helen Musyoka (1:01'10",2) and John Mwangangi (52'08",2) both from Kenya, won the 75th race from Morat to Fribourg, Switzerland, last Sunday. The distance is 10.48 miles. The race commemorates a mile stone in the struggle for self-determination. Read more here. Free will exists!

P.S: I still run regularly, inspired by the encouragement of loved ones, "The Penguin",and Joschka Fischer's book.I saw him often playing soccer in a park on Saturdays while returning from my duties as a bat warden at the Institute of Zoology. These days I am running on Spiras.







Friday, August 1, 2008

Auguste Forel & Brain Plasticity

Today the Swiss celebrate the founding of their confederation. The Swiss Confederation was conceived in a tax revolt more than 700 years ago, making Switzerland today's oldest post-classical European democratic republic governed on federal principles. I take this occasion to commemorate some of the achievements of the Switzerland's most eminent physician neuroscientist Auguste-Henri Forel. A summary of his contributions to neuroscience can be found at whonamedit.com.

Auguste-Henri Forel was born on September 1, 1848, in the wine country on the banks of Lake Geneva outside Lausanne. He attended secondary schools in Lausanne, but turned to the University of Zürich, when the time came to enroll for medical school. Young Forel loathed the decision. The move to Zürich entailed crossing the language barrier. It meant studying and being taught in German and living with people who speak a German dialect that is difficult to acquire. Even today, the francophonic region of Switzerland boasts only two full-track medical schools. Competition for posts is stiff and the pressure to conform is high. Auguste Forel apparently was made to realize early that he would not fit in. Besides, German universities were famous for the great scientific discoveries of the time, appealing strongly to the young inquisitive mind.

The sacrifice of home paid off for Forel. In the Teutonic sphere, he enjoyed an outstanding career as a psychiatrist and neuro-anatomist, working with a number of highly-respected researchers of the 19th century. He helped to establish a theory of the neuron still valid today. His was the first theory that recognized the role of the nerve cells as independent fundamental building blocks of the networks that process information in the brain. He was appointed director of one of the earliest psychiatric research hospitals in continental Europe. At this institution, he examined the effects of alcoholism on the brain. He was one of the first psychiatrists to study human sexuality with scientific methods. In his book on this subject, he did not shy away from discussing homosexuality and other cultural taboos of his time. He wrote legal opinions on the implications of mental illness for criminal code. He understood that every act of our mind had a molecular mechanism in the brain. An account of his writings on the human condition and the ensuing controversies can be found at Humbolt University's Archive for Sexology.

In addition to research on the human brain and mind, Forel developed a passion for the behavior of social insects at an early age and became a reputed specialist in ant taxonomy. After retiring from his duties as hospital director, he returned to the vineyards of francophonic Switzerland. The village where he settled, Yvorne, is located in the Rhone valley upstream from Lake Geneva about an hour's drive from his birth place. His residence became known as the Ant Hill. He devoted his time completely to the study of ants until his death at age 84, though he remained passionate about the curse of alcoholism and other human causes.

The locals remember him as an oddball ant lover who walked through their vineyards ranting and raving about their drinking habits. Obviously, the condemnation of wine consumption was at odds with the vintners' idea of their pleasurable products for refined tastes that constituted their livelihoods. Otherwise, they got along fine. Alas, the most prominent inhabitant of the village did not affect life in the village one single bit. Now as then, the smell of freshly pressed grapes permeates the air every September.

Moreover, Forel never managed to become truly accepted by the academic establishment of his francophonic homeland. He had to go through great troubles to obtain a medical license for this region and was never offered an academic appointment, regardless of his extraordinary scientific achievements and international acclaim. Only the burghers of Lausanne and Geneva know the reasons. Jean Calvin's ideals loom large there. Perhaps, Forel was too famous for them. By contrast, on the national level Auguste-Henri Forel was held in highest esteem. He was honored with a portrait on the largest denomination of the Swiss currency worth approximately $1,000.-. The banknote was in circulation until the year 2000. It was withdrawn because of counterfeiting. Its backside featured engravings of a neuron and an ant. I do not know of any other banknote dedicated to the brain and behavioral sciences.

I learned about Forel's research when I was working at the Institute of Anatomy of the University of Lausanne medical school. My colleagues and I were studying the influence of sensory input on brain development. I used the mouse somatic sensory system as a model. I already described the peculiarities of this system in my post dated May 15, 2008. The whiskers on the mouse's snout are represented topographically in the cerebral cortex of the brain by cytoarchitectonic units called barrels. The fifth cranial nerve, also known as the trigeminal nerve, innervates the face. Sensory trigeminal nerve fibers connect the pressure-sensitive receptor cells in the whisker follicles to the trigeminal sensory brainstem. From the brainstem the pathway crosses over to the other side and the input is relayed via the somatic sensory thalamus to the appropriate barrels in a one whisker-to-one barrel fashion.

Barrels develop in the first week after birth. When whisker follicles are removed at birth the corresponding barrels do not develop and the neighboring barrels enlarge. The critical period in which the barrels are plastic ceases once they are formed. The topographic order of the whisker input to somatic sensory cortex and its plasticity make the mouse whisker-to-barrel pathway a particularly useful model to examine the instructive power of sensory input on the development of sensory representation in the brain.

I set out to compare functional whisker representations in somatic sensory cortex, that is the areas whisker deflection activates in metabolic imaging, with the barrels. The follicles of select whiskers were removed in the critical period of brain development and in maturity. Early in his career, Auguste Forel conducted experiments, the results of which were instrumental to the hypotheses in my research.


The pictures above show a view of Yvorne (top, left), Forel at work in the Ant Hill (top, right), microscopic drawings of sections through the brainstem stained for nerve cells and fibers (bottom, left), and his description of the findings (bottom, right). He had examined in rabbits the consequences of cutting the trigeminal nerve at the root where it enters the brain. The microscopic drawings above show the nerve cells receiving the sensory trigeminal input (pink) and bundles of incoming trigeminal nerve fibers (brown) in the brainstem with an unperturbed trigeminal nerve (left) and after a nerve cut (right). Forel was probably the first to document a glial reaction to injury in the nervous system. Glia are types of brain cells distinct from nerve cells. They provide maintenance and support the immune response in the brain. I have written about this discovery in my post dated Dec. 16, 2007.

Important to his theory of the neuron, Forel noted that the incoming nerve fibers considerably diminished in number after the cut, whereas the density of nerve cells appeared increased. Careful, subsequent analysis showed that the increase in density resulted from tissue shrinkage. The number of nerve cells actually remained unchanged. This finding suggested that the cells of the nervous system were not fused into a continuous web as some scientists believed at the time. By contrast, the cells constituted independent members of an indirectly-connected network. In this network, no single member needed to show all functional attributes of the whole inasmuch as the behavior of a single ant does not reveal the destiny of the colony. The Gestalt psychologists would pick up on this idea and propose that in matters of brain and mind the whole was more than the mere sum of the pieces. I wrote about this school of thought in my post dated June 6, 2008. The cellular structure that permits communication between nerve cells without fusion is known as synapse today and was discovered only with the advent of the electron microscope half a century later.

The cell bodies of the trigeminal nerve fibers lie between the nerve's root at the brain and the nerve's endings in the skin. Forel cut the nerve at the root resulting in the degeneration of the projections that innervate the brainstem of the central nervous system. The severed central projections do not regenerate. By contrast, the removal of whisker follicles in my studies disrupted the peripheral trigeminal sensory projections innervating the mouse's face. Peripherally projecting nerve fibers regrow vigorously and attempt to find targets in the skin, particularly in the mature nervous system. Properly guided, they are able to restore functional innervation. I experienced the potential of restoration myself in two instances with opposite outcomes.

In addition to the face's skin, the trigeminal nerve innervates our teeth. At one time, I had to undergo orthodontic surgery to treat an inflammation in a root canal. During the procedure the branch of the trigeminal nerve that innervates the lower jaw and lower lip was crushed. My cheek and half of the lip remained numb after the anesthesia had worn off. But within six weeks, sensation returned successively, progressing toward the tip of the lip. I still vividly recall the moment when the numbness on the lip vanished with a slight tingling sensation and my sense of touch was completely restored. Apparently, the regenerating nerve fibers had successfully found their targets.

I was less fortunate on another occasion. I accidentally cut myself deep in the palmar surface of the right index finger, partially severing its sensory innervation. The accident happened 30 years ago. Half of my finger remains numb today. I have to be careful when I open bottles with twist caps, because I do not feel the pain before it is too late. Obviously, the regrowing nerve fibers were not able to bridge the injury and re-innervate the skin. They lacked the guide of the sheeth wrapping the nerve. The nerve stumps had become separated and misaligned in the accident. Today, surgeons are careful to reconnect nerve sheeths in reconstructive procedures to ensure optimal restoration of innervation.

Forel's insights into the relationships between ants and nerve cells spawned a number of hypotheses in my work about possible nerve cell responses to the loss of sensory input. I imagined the ensemble of nerve cells interacting in the brain in analogy to an orchestra of ants, the Orchestre de Mille Francs, OMF for short. The members of the OMF grow up and learn to play music together. Each member must play their instrument in context of the music the other members play. Though the members are independent players, they need to listen to one another and coordinate their actions in order to perform in meaningful symphony. What would happen if members break their instrument? What would happen if they break a limb? Can the remaining members substitute? Does it depend on the kind of instrument the member was playing? Would the music change? Could the melody be restored? Did the changes depend on the proficiency of the players? Was the potential for change greater with beginners than with seasoned virtuosos? The drawings shown below helped flesh out possible scenarios.

L'orchestre de mille Francs

One intriguing finding of my mouse studies was that the functional cortical representations of the intact whiskers adjacent to the removed ones enlarged into the territory left vacant by the removal. The functional whisker representations were modified even when whisker follicles were removed in adult mice long after the critical period for barrels had ended. This plasticity of functional sensory representation may provide a basis for the perception of a continuous tactile field while the sensory nerve fibers in the facial skin reorganize. The regeneration of peripheral innervation is particularly strong when the nervous system is mature. My studies and the studies of others showed that whisker follicles remaining in the skin attract the newly regenerated nerve fibers and are innervated by them within three months. The findings suggest that it may be worthwhile to surgically provide guides for regrowing nerve endings months after the disruption of innervation. An extended program of exercises providing continued sensory stimulation may help boost new functionality.

Addendum


Sunday, June 22, 2008

Morat: Triumph of Free Will

“The idea of America endures. Our destiny remains our choice.  And tonight, more than two centuries later, it’s because of our people that our future is hopeful, our journey goes forward, and the state of our union is strong.”
President Barack H. Obama in his State of Union Address, Jan. 25, 2011 (added on the following day).

Today, Jun. 22, in 1476, the Swiss Confederation won a decisive battle against Charles II, Duke of Burgundy, known as the Bold. This account of the event is mainly based on the Freiburger Geschichtsblaetter, vol. 60 (1976). A good summary is available on the web here. A formidable depiction of the battle can be found here. Charles II was a highly educated feudal lord with a penchant for war as a tool to fulfill his territorial ambitions. This renaissance ruler oversaw a wide swath of land across Western Europe from the shores of the North Sea to the shores of the Mediterranean. The wealthy Swiss cities on the Eastern borders of his realm infringed upon his zone of influence and also promised a good additional source of income for his treasury. From adolescence, the Duke was unrelenting in his effort to keep the wealthy cities of the low lands on the North Sea under his control. A campaign to subdue wealthy Swiss cities was an eastward extension of this policy.

In January 1476, Charles marched an army of about 28,000 professional soldiers equipped with the most advanced artillery of his time toward Western Switzerland. The region around Lake Geneva was under the rule of the Count of Savoy who was allied with the Duke. On February 8, the troupes crossed the Jura mountains into Switzerland and soon attacked the town of Yverdon on the banks of Lake Neuchâtel. The town had been occupied by the Swiss Confederation in the preceding year. Now the occupiers abandoned their position, burning down everything behind them. They withdrew to the fortress at nearby Grandson with the Duke's men in hot pursuit. The Duke ordered a siege. On February 21, the Confederates surrendered on promise of free conduct. As the men filed across the drawbridge disarmed, they were taken to a mighty tree nearby and hanged one next to the other from its branches. The fortress has survived intact and houses the municipal administration today. The tree also survived. It is huge with numerous massive, horizontal branches. There is easily space for a score of bodies on each. Contemporary depictions of the despicable act show rows of corpses strung up like chicken on a line. Reportedly, a total of 412 men were strung up in the tree within 4 hours.

In retaliation, the Confederates surprised the Duke's army in the vicinity of Grandson on February 27 and captured a good part of the artillery. Most importantly, they happened upon the Duke's treasure of legendary riches. Its bounty was so exorbitant that the looters fought over their shares for a number of years. A peace treaty was needed to put the quarrels aside for once and all.

The gruesome end of the Confederates at Grandson sent a clear message to the towns in the region. Commonly, the burghers avoided armed conflict. Negotiating an agreement with the aggressors, even if it was costly, was often less disastrous than battle. Moreover, the burghers in West Switzerland did not care whether they paid taxes to some feudal lord or the city of Berne which dominated the region. Moreover, the francophonic locals felt more comfortable with the French culture of the Duke than with the Teutonic culture of the Swiss Confederates. Many small towns would have immediately switched sides in the face of the ducal forces, had the conditions of surrender seemed decent and fair. But, the horrible events at Grandson proved to the burghers that they could not expect benevolence from the Duke.

The second Burgundian thrust into Confederate territory started in June with a regrouped army of 21,000 men from fields above the city of Lausanne. On the march to the city of Berne, the army reached the town of Morat on the banks of the lake with the same name. The Burgundians began to lay siege on June 9.

The Bernese government had preempted a negotiated surrender of the town by sending the experienced commander Adrian of Bubenberg to oversee the local garrison. He ascertained that the burghers resolve did not falter in the bombardment of the Burgundian artillery. They had to hold out until the very end which was close on June 22. The Duke's heavy artillery had been persistently pounding the town's defenses. The wall and a tower had already crumpled in on the northern side three days earlier, but the defenders had repulsed the enemy's advance through the breach after eight hours of fighting. Now, it was only a question of time, until other breaches were wide enough for a final assault.

Bubenberg had written desperate pleas for help to Berne. The members of the Swiss Confederation were gathering an army to confront the Burgundians, with the Bernese constantly reminding the others of the oaths of mutual support they had sworn. This was no easy feat. The Swiss Confederation was not directed by a ruler, but was led by consensus. Plenty rivalry existed between regions and towns. Heated debates were raging whether it was wise or profitable enough to come to the rescue of the Bernese. Some compatriots felt it best to stay out of a conflict that did not affect them directly. In Zurich, the final decision to join the cause fell only days before the battle. Once it was made, 4,000 soldiers force-marched the 70 miles from Zurich to Morat in three days. Six-hundred did not arrive. During the night of June 22, the Zurichois united with the 25,000 Confederates and allies from Alsace and Lorraine that were already assembled behind a forest about 3 miles from the Duke's positions. Now, the Swiss outnumbered the Burgundians.

The Confederates had found in the Southern German Herter of Hertenegg an expert military leader for their endeavor. With the help of the Swiss captains, he managed to expediently whip the diverse lot into an attack formation that was classic in his time. The men were divided into a 5,000-strong avantguard, a 10,000-strong bulk and, arguably, a rear guard made of the rest of the troupes. The three battle groups were to enter the battle field in close succession. The avant guard was supported by 1,100 cavalry deployed on their left. Avantguard and bulk were to advance tightly packed in arrow formation with lancers wearing body armor on the flanks protecting the less armored helbard bearers in the middle from enemy projectiles.

Jockeying for the best positions and the most valiant jobs lasted into the morning. Promotions were handed out. The arguing went on. But the Swiss could not wait any longer. The militia men did not have any provisions. Hertenegg and 500 men rode to the forest's edge to view the enemy positions. Meanwhile, deployment for battle continued in the forest, though heavy rain fell.

The Duke's soldiers had been expecting the Swiss for days. They knew the location where they would emerge from the forest. The Duke's planners had set up a palisade fence and other fortifications to corral the Swiss militia men into a trap in the shape of an L with the short stroke, that is the line of artillery, pointing upwards and the long stroke, that is the line of archers, pointing sideways. On arrival the Swiss would be annihilated in a hail of arrows from the front and cannon fire from the right side. The enemy's left side opposite the artillery was left open for the charge of 2,100 cavalry, waiting behind the lines ready to mop up.

The Burgundians had been lying in their battle positions for several hours on this day and for hours on end on the days before. As on the other days, the enemy did not seem to attack. The weather was abysmal and lunchtime approached. The officers decided to stand most troupes down. At this very moment, the rain stopped and sun broke through the clouds. The Swiss avantguard advanced. The bulk of the force followed on their heals. The men poured against the Burgundian fortifications and were welcomed by arrows and artillery. Though only skeleton crews were at hand, the Burgundian army unleashed dense clouds of projectiles. Despite, the fiercely determined Swiss avant guard managed to breach and circumvent the fortifications within an hour. The cannon fell silent. The bulk of the Swiss force spilled like an avalanche through the breaches toward the Burgundian camps ringing the town. The Burgundians did not have a chance to ready themselves. Disarray and mayhem ensued. The Duke's officers tried to organize a counter offensive. The line faltered. The men took flight. A complete route unfolded. The Swiss succeeded in surrounding the fleeing troupes on three sides. The fourth side was taken by the lake. Countless Burgundian soldiers drowned or were drowned in a desperate attempt to flee across the water. It is said that a third of the Duke's army perished. The Duke and his immediate household escaped narrowly.

Louis Braun, Schlacht bei Murten, 1893
Lore has it that at the day's end, the Confederate contingent from the city of Fribourg sent a messenger home with a branch from a linden tree to announce the victory. The distance is about 11 miles. There are two steep grades on the way and a final 0.7-mile ascend through Fribourg toward downtown. The branch of the tree was supposedly planted in front of City Hall in memory of the great battle. A massive linden actually stood there until about 30 years ago. Sadly, it succombed to pollution. But, for 75 years the messenger's feat has been commemorated by a run held on the first Sunday in October.

Tens of thousands of people from all over the world attend. Olympic medalists cover the distance in a bit more than 40 minutes. Morat looks very much the same today as it did at the time of the battle. Ramparts and towers survived.

Charles the Bold was a military man to the hilt whose confidence in battle was strengthened by several successes at young age. He was an involved leader and said to be popular with the soldiers. At the height of his Swiss campaign, he slept in battle dress until his limbs swell and he could not walk. He involved himself deeply and directly even in small affairs to the point that his commanding officers loathed his interference. On the downside, his inability to accept advice and his mistrust of those who were not members of his immediate household may have impeded effective leadership.

Yet, the strategy Charles used at Morat was consistent with the military thinking of his time. History had proved that victory belonged to those who picked the location of the fight and could prepare the battle field to their advantage. This commonly outweighed the disadvantage of having to wait for the enemy. The Duke commanded the best weapons of his time. He had introduced innovative battle formations combining different types of soldiers into fighting units in which they could complement each other. His standing army consisted of experienced professionals and practiced regularly. After the battle, the foreign military observers present and the Duke himself blamed the debacle on ill timing. Had everybody been on their battle stations, the Swiss would have perished for certain.

However, it can be argued that the Burgundian soldiers, most of whom were contracted, were no match against the independently-minded militia. The Swiss were bound only by their determination to win. Otherwise they were free to take any decisions they saw fit in the field.

The Duke's greatest flaw may have been his own inflexibility in judging the Swiss. This renaissance man fatefully stood on the threshold between the old and the new. He embodied the contradictions of a modern minded leader who loved technical innovation, but could not grasp the novelty in his enemy's mindset. The Swiss militia may have used crude, antiquated strategies on the battle field. Yet, they were motivated by a consensus solidly forged by communal deliberation. Common people making own decisions of this magnitude had no place in the feudal system. Charles II was a proponent of the God-given order in which he and his kind were entitled to all worldly decisions. Granting commoners too much freedom would bring only chaos. The Duke's subjects were rewarded as long as they gladly played the roles he assigned them in fulfillment of God's will. He saw it as his duty to severely punish those who rebelled against this order. Change was not acceptable.

At the time, the victory of the Swiss Confederates sent a profound signal across Europe. Like any other victory of commoners against feudal lords, this one proved that anyone could prevail, if they were free to use their abilities to the fullest. Success against the odds was possible, when the like-minded exercised solidarity and broadly shouldered the burden of action. The example of the Swiss Confederates demonstrated that anyone with resolve, unrestrained by feudal bondage and station, could take destiny in their own hand, take advantage of their abilities and use them to improve their circumstance of life. The events at Morat were at the beginning of a movement that would eventually lead to the Declaration of Independence and the Storming of the Bastille 300 years later. The persistent determination of the common people to free themselves from the feudal yoke precipitated the standard of living and the freedoms we enjoy today.

Addendum
  • In his post on boingboing.net today entitled "Draft of Declaration of Independence named subjects, not citizens", Rob Beschizza describes in detail how Library of Congress researchers using hyperspectral imaging recently discovered an important change in Thomas Jefferson's draft of the Declaration of Independence. He first wrote "subjects", smudged out the wet ink, and replaced the word with "citizens". This small, willful change constitutes such an extraordinary example for the sea change in zeitgeist in Jefferson's time, reflecting the end of feudalism and the beginnings of modern society. It is yet another prove that free will exists (07/03/10).

Thursday, May 15, 2008

Human Frontiers, Brains & Space

Today, I saw for the first time a person suspended from a set of jet-powered wings in free flight. Reuters provides footage of this stunning performance that took place yesterday near Bex,VD, Switzerland, on May 14, 2008.


The pilot, Yves Rossy, successfully managed to soar at great altitude out from the Alps into the Rhone Valley below, proving to the world once more that something seemingly impossible can be achieved after all.

Alas, observing the audacious aviator looping at break-neck speed high in the sky gave me pause. The breath-taking footage rendered a vivid picture of the fragility of the human body. I was reminded of our modern day frontiers and the yet unknown limitations they may impose upon us.

Multiple nations help maintain a permanently-inhabited space station in orbit around Earth. According to the National Air and Space Agency, the U.S. president is firm in the Federal Government's continued commitment to manned interplanetary space flight. The BBC reports that the Peoples Republic of China aims to establish a human presence on the moon in the next decade. Reuters reports that the Russian and the European Space Agencies may join in the development of a spacecraft capable of transporting personnel to the moon. In the face of such ambitions, it is important to understand that we actually know little about the effects that extended tours in weightlessness may have on our body.

As John Steinbeck aptly described in his book The Log from the Sea of Cortez (chapter 4), all organisms on Earth develop and live under the influence of the planet's gravity and its tidal changes imposed by the lunar pull. I have not found a study yet that sheds a light on the question whether a mammalian brain develops normally in the absence of these forces.

Animal models are available to answer this fundamental question. For example, in layer IV of the mouse's somatic sensory cortex cell aggregates known as barrels topographically represent the whiskers on the face.
The picture on the right (courtesy of H. Van der Loos) shows a micrograph of an 80 micrometer-thick section cut tangentially through the left cerebral hemisphere of a Swiss Webster mouse cortex embedded in celluloidine. The left side is up. The nose is right. The section was stained for cell bodies with a blue dye. The barrels are clearly visible as nerve cell-dense rings surrounding cell-sparse centers. The large barrels are arrayed in five oblique rows representing the five rows of long whiskers on the snout. The whiskers on the face are sensory hairs with thousands of touch receptors embedded in their roots. The nerve cells in a cortical barrel respond most vigorously to deflections of the whisker the barrel represents. The barrels develop during the first week after birth. If a whisker is damaged at birth, the corresponding barrel will not develop, suggesting a strong influence of the sensory periphery on cortical development.

Examining the brains of mice taken to the space station shortly after birth for a week would inform us immediately whether microgravity gravely disrupts brain development.

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In this grasping adventure story for kids, Brian Greene explains in most insightful and easy-to-understand fashion the relationship between gravity, speed and time.



Wednesday, December 5, 2007

About Taking Risks



The Eidgenoessische Technische Hochschule (ETH) in Zurich, Switzerland, is an astounding institution of higher learning. Literally, the name translates into English as “Federal Technical High School”. "Federal", because the Swiss federal government supports the institution. "Confederal" would be more appropriate, because the Swiss define their nation as the Confederation of the Swiss. The acronym on their trunk stickers reads CH for confederatio helvetiae, which means Confederation of the Swiss in Latin. Latin was the language of the learned when the Swiss founded their Confederation more than 700 years ago with an oath sworn to help each other. “Eidgenossenschaft”, the German term for the Confederation, means comradeship by oath. The ETH is not a High School. That would be a “Gymnasium” in the Teutonic Languages. It is an engineering school. I use statistical analyses frequently. The ETH helps to develop R, which is one of the most powerful and versatile statistics packages available in open source computing.

In the year 2000, the ETH launched a research initiative in risk assessment. When I heard of this idea, I thought: ”Typically Swiss! They always worry about insurance.” When I checked, most projects aimed at assessing risks in civil engineering and catastrophic damage. But, I bet the principles guiding the software find ready application in the assessment of other types of risk. Just a few weeks ago CEO Charles Prince resigned, because his bank had incurred tantamount losses while dabbling in high-risk investments in sub-prime lending (Dan Wilchins and Jonathan Stempel's post on Reuters dated Nov. 2, 2007, with the title "Citigroup CEO Prince to resign: reports"). What did he blame? Faulty software that was making bad predictions on risk! In his testimony before the Committee on Oversight and Government Reform,  Mar. 7, 2008, he blames the models the industry was using. Perhaps, he should have consulted with the ETH, before he decided to go down that road.

Addenda

  • In hindsight, the bank managers heavily relied on these tools in their decisions. However, even at UBS they did not comprehend them well enough to interpret the data correctly (08/01/2008).
  • At yesterday's congressional hearing, Citigroup's former CEO Charles Prince apologized to Americans hurt by the financial crisis that Citigroup helped precipitate in no small part. He believes that risk reporting within the institution at the time was not at fault and followed good practices. Rather, faulty risk assessment caused the bank's enormous losses. He had come to this conclusion already three years ago (see above). However, now responsibility is shifted to the originators of the bad loans. Prince seems to believe that Citigroup was misled by the original lenders' overoptimistic judgment of the customers' ability to service subprime mortgages. As a result, the risk attached to the securitized bundles containing these loans was understimated and the price at which they were sold to investors was overrated. Listen closely (04/09/10)!
  • Contrary to the former CEOs of Lehman Brothers, Citigroup and Washington Mutual, some in the industry understood the risk attached to subprime lending extremely well.

    On Apr. 22, 2010, Carrick Mollenkamp, Mark Whitehouse and Anton Troianovski published an informative chronicle in The Wall Street Journal entitled "The Busted Homes Behind a Big Bet" of the events surrounding a collateralized debt obligation, or CDO for short, named Abacus that achieved notoriety lately as an example for the catastrophic failure of securitized mortgage bundles that precipitated this country's greatest economic crisis since the Great Depression while providing its creators with extraordinary returns.

    In 2007, Paulson & Co., a hedge-fund management company, helped create Abacus 2007-AC1 for institutional investors in collaboration with Goldman Sachs and the portfolio selection-agent ACA Management, LLC. Within the next six months, Abacus would lose 83 percent of its value.

    Paulson & Co. had painstakingly analyzed the mortgages bundled in Abacus and correctly predicted that great losses were inevitable and soon to come. A senior employee of the firm, Paolo Pellegrini, was deeply involved in structuring Abacus. According the Wall Street Journal article, " Mr. Pellegrini and a colleague had purchased an enormous database capable of tracking the characteristics of more than six million mortgages in various parts of the country. They spent long hours scouring it all, according to people familiar with the matter." Paulson and Co. took out insurance against the CDO's demise, cashing out a billion dollars at its end.

    Apparently, correct models for risk assessment and data bases with the necessary information were available to those who wished to come to the right conclusions (04/25/10).
  • This Reuters video report by Bobbi Rebell with the title "Camping out for a change" published today portrays a new political movement that attempts to harness people's feared risk of being set adrift by those with a seemingly insatiable appetite for it. Within the past decade, risk assessment has become the overarching theme of our time (10/10/2011).
    (Thumbnail photo by Lucy Nicholson, Reuters)

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